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Heartgard Plus Dogs 26-50 lbs
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Heartgard Plus Dogs 26-50 lbs

Given once a month for life HEARTGARD Plus is the easiest way to help protect your pet from deadly heartworm disease. HEARTGARD Plus also treats and controls hookworms and roundworms.

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Item# Size/Desc Qty Price
6 Dose
Save $7.00   
This item requires a RX
12 Dose
Best Deal Save $12.00
Item qualifies for FREE SHIPPINGThis item requires a RX

**Note: This product requires a veterinarian's prescription to purchase.At checkout you will need to provide your veterinarian's FAX or email address. We will then send him or her a prescription verification that he or she will need to sign and return before we can ship you this product.

All dogs should be tested for existing heartworm infection before starting treatment with HEARTGARD Plus which is not effective against adult D. immitis. Infected dogs must be treated to remove adult heartworms and microfilariae before initiating a program with HEARTGARD Plus.

How does Heartgard Plus for Dogs work?:

 Heartgard Plus for dogs works to prevent canine heartworm disease by eliminating the tissue stage of heartworm larvae Dirofilaria immitis for a month 30 days after infection and for the treatment and control of ascarids Toxocara canis, Toxascaris leonina and hookworms Ancylostoma caninum, Uncinaria stenocephala, Ancylostoma braziliense.


HEARTGARD® Plus ivermectin/pyrantel Chewables should be administered orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram 2.72 mcg/lb and 5 mg of pyrantel as pamoate salt per kg 2.27 mg/lb of body weight. The recommended dosing schedule for prevention of canine heartworm disease and for the treatment and control of ascarids and hookworms is as follows:

Weight                      Tablet Per Month                   Carton

Up to 25                        1                                   Blue

26 to 50                         1                                  Green

51 to 100                       1                                  Brown


HEARTGARD Plus is recommended for dogs 6 weeks of age and older. For dogs over 100 lb use the appropriate combination of these Chewables.

How do I give Heartgard Plus to my dog?:

    Remove only one chewable at a time from the foil-backed blister card.
    Return the card with the remaining Chewables to its box to protect the product from light.
*     Because most dogs find HEARTGARD Plus palatable, the product can be offered to the dog by hand.
*     Alternatively, it may be added intact to a small amount of dog food.
*     The chewable should be administered in a manner that encourages the dog to chew, rather than to swallow without chewing.
*     Chewables may be broken into pieces and fed to dogs that normally swallow treats whole. 
*     Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes after administration to ensure that part of the dose is not lost or rejected.
*     If it is suspected that any of the dose has been lost, redosing is recommended.

How often do I give Heartgard Plus to my dog?:

HEARTGARD Plus should be given at monthly intervals during the period of the year when mosquitoes vectors, potentially carrying infective heartworm larvae, are active.  The initial dose must be given within a month 30 days after the dog&rsquos first exposure to mosquitoes. The final dose must be given within a month 30 days after the dog&rsquos last exposure to mosquitoes.  When replacing another heartworm preventive product in a heartworm disease prevention program, the first dose of HEARTGARD Plus must be given within a month 30 days of the last dose of the former medication.

If the interval between doses exceeds a month 30 days, the efficacy of ivermectin can be reduced. Therefore, for optimal performance, the Chewable must be given once a month on or about the same day of the month. If treatment is delayed, whether by a few days or many, immediate treatment with HEARTGARD Plus and resumption of the recommended dosing regimen will minimize the opportunity for the development of adult heartworms.

Monthly treatment with HEARTGARD Plus also provides effective treatment and control of ascarids T. canis, T. leonina and hookworms A. caninum, U. stenocephala, A. braziliense. Clients should be advised of measures to be taken to prevent reinfection with intestinal parasites.


All dogs should be tested for existing heartworm infection before starting treatment with HEARTGARD Plus which is not effective against adult D. immitis. Infected dogs must be treated to remove adult heartworms and microfilariae before initiating a program with HEARTGARD Plus.

While some microfilariae may be killed by the ivermectin in HEARTGARD Plus at the recommended dose level, HEARTGARD Plus is not effective for microfilariae clearance.  A mild hypersensitivity-type reaction, presumably due to dead or dying microfilariae and particularly involving a transient diarrhea, has been observed in clinical trials with ivermectin alone after treatment of some dogs that have circulating microfilariae. Keep this and all drugs out of the reach of children.

In case of ingestion by humans, clients should be advised to contact a physician immediately. Physicians may contact a Poison Control Center for advice concerning cases of ingestion by humans.

Store at controlled room temperature of 68°F - 77°F 20°C - 25°C. Excursions between 59°F - 86°F 15°C - 30°C are permitted. Protect product from light.


In clinical field trials with HEARTGARD Plus, vomiting or diarrhea within 24 hours of dosing was rarely observed 1.1% of administered doses.  The following adverse reactions have been reported following the use of HEARTGARD: Depression/lethargy, vomiting, anorexia, diarrhea, mydriasis, ataxia, staggering, convulsions and hypersalivation.


 HEARTGARD Plus has been shown to be bioequivalent to HEARTGARD, with respect to the bioavailability of ivermectin. The dose regimens of HEARTGARD Plus and HEARTGARD are the same with regard to ivermectin 6 mcg/kg. Studies with ivermectin indicate that certain dogs of the Collie breed are more sensitive to the effects of ivermectin administered at elevated dose levels more than 16 times the target use level than dogs of other breeds. At elevated doses, sensitive dogs showed adverse reactions which included mydriasis, depression, ataxia, tremors, drooling, paresis, recumbency, excitability, stupor, coma and death. HEARTGARD demonstrated no signs of toxicity at 10 times the recommended dose 60 mcg/kg in sensitive Collies. Results of these trials and bioequivalency studies, support the safety of HEARTGARD products in dogs, including Collies, when used as recommended.  HEARTGARD Plus has shown a wide margin of safety at the recommended dose level in dogs, including pregnant or breeding bitches, stud dogs and puppies aged 6 or more weeks. In clinical trials, many commonly used flea collars, dips, shampoos, anthelmintics, antibiotics, vaccines and steroid preparations have been administered with HEARTGARD Plus in a heartworm disease prevention program.  In one trial, where some pups had parvovirus, there was a marginal reduction in efficacy against intestinal nematodes, possibly due to a change in intestinal transit time.

Heartgard is manufactured by and is a registered trademark of Merial.  The information provided on this website is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. We reference Merial as the source for our information. You should always consult your own veterinarian for specific advice concerning the diagnosis, and treatment of your pet. As stated the information provided is for educational purposes to aid you in purchasing your pet's medication, it is not a substitute for a veterinary exam, nor does this information suggest that this medication will be tolerated by your pet or that your pet will not experience side effects.
Note: Any trademarks are the property of their respective companies.