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Legend® hyaluronate sodium is the only FDA approved I.V. and intra-articular therapy to treat equine non-infectious synovitis associated with osteoarthritis. Legend is pure hyaluronate sodium, the same glycosaminoglycan present in normal joint fluid. Legend is produced by a patented biofermentation process, resulting in such purity that it can be given intravenously for immediate bioavailability.

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Item# Size/Desc Qty Price
9063
Injectable 10 mg/ml, 2 ml vial=20mg
$65.99
$50.99
Save $15.00!  
Item qualifies for FREE SHIPPINGThis item requires a RX
9064
Injectable 10 mg/ml, 4ml vial=40mg
$95.99
$81.99
Save $14.00!
Item qualifies for FREE SHIPPINGThis item requires a RX
9065
Injectable 20 ml vial
$365.99
$367.99
Item qualifies for FREE SHIPPINGThis item requires a RX

**Note: This product requires a veterinarian's prescription to purchase.At checkout you will need to provide your veterinarian's FAX or email address. We will then send him or her a prescription verification that he or she will need to sign and return before we can ship you this product.


Key Benefits

Legend, because of its unique purity, can be given intra-articularly or intravenously. I.V. administration provides the following advantages:

  • Safety
    • No need to invade the joint with a needle, risking bacterial entrance, physical trauma to joint tissues or intra-articular injection reactions.
    • Safety in breeding animals has not been determined.
    • Federal law restricts this drug to use by or on the order of a licensed veterinarian.
    • For use only in horses. Do not use in horses intended for human consumption.
  • Convenience
    • No shaving or surgical preparation of the joint.
    • IV administration to treat multiple joints.
    • Available in a larger, 20mL Multi Dose vial for Intravenous use only.
  • Efficacy
    • Proven to decrease inflammation and destructive enzymes associated with inflammation.1
    • Rapid onset of action. I.V. administration helps ensure a quick onset of action resulting in a rapid decrease in inflammation.
  • Applications
    • Legend 2mL, For Intravenous and Intra-Articular use
    • Legend 4mL, For Intravenous use only
    • Legend Multi 20mL, For Intravenous use only
      The intra-articular safety of Legend Multi dose with benzyl alcohol has not been determined.

      How Supplied:

      Legend Injectable Solution is supplied in 2 mL 20 mg and 4 mL 40 mg vials. Each mL contains 10 mg hyaluronate sodium, 8.5 mg sodium chloride, 0.223 mg sodium phosphate dibasic, and 0.04 mg sodium phosphate monobasic. The pH is adjusted to between 6.5 and 8.0 with sodium hydroxide or hydrochloric acid.

      Legend Multi Dose Injectable Solution is supplied in 20 mL vials. Each mL contains 10 mg hyaluronate sodium, 8.5 mg sodium chloride, 0.223 mg sodium phosphate dibasic, 0.04 mg sodium phosphate monobasic and 15.63 mg benzyl alcohol as a preservative. The pH is adjusted to between 6.5 and 8.0 with sodium hydroxide or hydrochloric acid.


      DOSAGE AND ADMINISTRATION:

      Legend Multi Dose 20 mL and Legend 4 mL 40 mg injected intravenously only. Legend 2 mL 20 mg injected intravenously or intra-articularly in the carpus or fetlock.

      Treatment may be repeated at weekly intervals for a total of three treatments.

      Legend Injectable Solution 2 mL: Strict aseptic technique should be observed when administering by intra-articular injection. As with any intra-articular procedure, proper injection site disinfection and animal restraint are important. Excess joint fluid should be aseptically removed prior to injection. Care should be taken to avoid scratching the cartilage surface with the tip of the injection needle. Diffuse swelling lasting 24 to 48 hours may result from movement of the needle while in the joint space.

      For intravenous administration, use aseptic technique and inject slowly into the jugular vein.

      Horses should be given stall rest after treatment before gradually resuming normal activity.

      Legend Injectable Solution 2 mL and 4 mL only: Discard any unused portion of the drug and the empty vial after opening.

      CONTRAINDICATIONS:

      There are no known contraindications for the use of Legend® hyaluronate sodium Solution and Legend® Multi Dose hyaluronate sodium Injectable Solution in horses.

      RESIDUE WARNING:

      Do not use in horses intended for human consumption.

      HUMAN WARNINGS:

      Not for use in humans. Keep this and all other drugs out of reach of children.

      ANIMAL SAFETY WARNING:

      For 4 mL only - Not for Intra-articular use.

      Multi Dose not for Intra-articular use. The Intra-articular safety of hyaluronate sodium with benzyl alcohol has not been evaluated.

      PRECAUTIONS:

      Radiographic evaluation should be carried out in cases of acute lameness to ensure that the joint is free from serious fractures. As with any intra-articular Legend Injectable Solution - 2 mL only treatment, special precautions must be followed as to injection technique and sterility for prevention of possible swelling or infection. Intra-articular injections should not be made through skin that has been recently fired or blistered, or that has excessive scurf and counterirritant on it.

      The safety of Legend Injectable Solution and Legend Multi Dose Injectable Solution has not been evaluated in breeding stallions or in breeding, pregnant or lactating mares.

      ADVERSE REACTIONS:

      No local or systemic side effects were observed in the Legend Injectable Solution clinical field trials with either intravenous or intra-articular injections.

      Post-Approval Experience: While all adverse reactions are not reported, the following adverse reactions are based on voluntary post-approval reporting for Legend Injectable Solution:

      Following intravenous use: Occasional depression, lethargy, and fever.

      Following intra-articular Legend Injectable Solution - 2 mL only use: lameness, joint effusion, joint or injection site swelling, and joint pain.

      For medical emergencies or to report adverse reactions, call 1-800-422-9874.

      EFFECTIVENESS:

      Effectiveness studies utilizing Legend Multi Dose Injectable Solution were not performed. Legend Multi Dose Injectable Solution was approved based on the conclusion that the effectiveness of Legend Multi Dose Injectable Solution will not differ from that demonstrated for the original formulation of Legend Injectable Solution.

      Forty-six horses with lameness in either the carpal or fetlock joints were treated intravenously or intra-articularly with Legend Injectable Solution in a well-controlled clinical study conducted at four locations. One, two or three injections were given based on clinical improvement. Overall clinical improvement was judged as excellent or good in 90% of the cases treated intravenously and 96% of those treated intra-articularly with Legend Injectable Solution.

      We reference Bayer as the manufacturer and source for our information on Legend. For more information please click this website link: http://www.bayerdvm.com/Products/legend/legend.cfm