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Marquis Oral Paste is a prescription medication is used to treat equine protozoal myeloencephalitis EPM caused by Sarcocystis neurona.
Marquis is an oral Paste supplied in ready-to-use syringes containing 127 grams of paste.
Add this item to your cart:

Item# Size/Desc Qty Price
15% 127mg Syringe 4 count
Save $160.00   
Item qualifies for FREE SHIPPINGThis item requires a RX
15% 127 mg Syringe single dose
Save $31.00
Item qualifies for FREE SHIPPINGThis item requires a RX

**Note: This product requires a veterinarian's prescription to purchase.At checkout you will need to provide your veterinarian's FAX or email address. We will then send him or her a prescription verification that he or she will need to sign and return before we can ship you this product.


*  Marquis 15% w/w ponazuril Antiprotozoal Oral Paste offers proven efficacy against equine protozoal myeloencephalitis EPM

*  Ponazuril acts against the parasite at several stages of the lifecycle

*  Ponazuril crosses the blood/brain barrier to reach the central nervous system CNS where it kills the parasite.

*  Formulated in a low-volume paste that horses readily accept.

*  Administered once a day for 28 days.

*  Simple, low-dose regimen

*  Packaged with four syringe barrels and four reusable plungers with a calibrated dosing ring. Each syringe barrel contains enough ponazuril to treat one 1,200-pound horse for seven days.

Dosage and Administration:

Each syringe barrel of Marquis ponazuril contains enough paste to treat one 1 1,200 lb 544 kg horse for seven 7 days, at a dose rate of 5 mg/kg 2.27 mg/lb body weight.
The plunger contains a dosage ring calibrated for a dose rate of 5 mg/kg 2.27 mg/lb body weight and marked for horse weight from 600 to 1,200 lbs 272 to 544 kg.
The syringe barrels are packaged in units of four with four reusable plungers.
This package provides sufficient paste to treat one 1,200 lb 544 kg horse for 28 days at a dose rate of 5 mg/kg 2.27 mg/lb body weight.

Paste syringe assembly:
Before administration, the syringe barrel and plunger require assembly. Ensure plunger is clean and dry.

Step 1.

End cap must be on syringe barrel when inserting plunger.

Step 2.

Carefully insert reusable plunger into base of syringe barrel until it snaps into place, then remove end cap and gently apply pressure to the plunger until paste is seen at the tip of the syringe barrel.

Step 3.

Return end cap to tip of paste syringe.

Administering Marquis ponazuril to the horse:


The paste syringe is a multi-dose package. Ensure that the correct dose is administered with each use.

Step 1.

Remove end cap and gently apply pressure to the plunger until paste is seen at the tip of the syringe barrel. Return end cap to tip of paste syringe.

Step 2.

Determine weight of horse and insure the horse's mouth contains no feed.

Step 3.

To measure dose, dosage ring collar and barrel collar should be flush. Hold plunger and rotate dosage ring with the other hand to the weight of the horse.

Step 4.

Remove end cap from tip of syringe barrel.

Step 5.

The selected dose of paste should be deposited onto the back and top of the horse's tongue. Introduce tip of paste syringe into the side of the horse's mouth at the space between the front incisor and back molar teeth. Deposit paste on the horse's tongue by depressing the plunger of the syringe as far as the dose ring permits. Remove tip of syringe from horse's mouth.

Step 6.

To aid swallowing of paste, immediately raise horse's head for a few seconds after dosing.

Step 7.

Clean the tip of the syringe with a clean disposable towel and return end cap to tip of syringe barrel.

Step 8.

For the next daily dose, repeat steps 1-7.



For use in animals only.
Not for use in horses intended for food.
Not for human use.
Keep out of the reach of children.


Prior to treatment, EPM should be distinguished from other diseases that may cause ataxia in horses.
May see rashes, hives, blisters, diarrhea, signs of mild colic or seizures. Consult your veterinarian if you notice any of the above side effects.

If your horse experiences an allergic reaction to the medication, signs may include facial swelling, hives, scratching, sudden onset of diarrhea, shock, seizures, pale gums, cold limbs, or coma. If you observe any of these signs, contact your veterinarian immediately
Notify your veterinarian of any other medications, including vitamins and supplements, your horse is taking while receiving Marquis Paste.