UNIPRIM POWDER is a combination of trimethoprim and sulfadiazine in the ratio of 1 part to 5 parts by weight, which provides effective antibacterial activity against a wide range of bacterial infections in animals.
Trimethoprim 67 mg/gram and sulfadiazine 333 mg/gram. Palatable top-dressed broad-spectrum antibiotic for use in horses that is active against a wide spectrum of bacterial pathogens, both gram-negative and gram-positive, including Escherichia, Streptococcus, Proteus, Salmonella, Pasteurella, Shigella and Haemophilus. Indicated where potent systemic antibacterial action is required against abscesses, wound infections, urogenital infections, strangles and respiratory tract infections.
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INDICATIONS AND USAGE:
Trimethoprim/sulfadiazine is indicated in horses where potent systemic antibacterial action against sensitive organisms is required. Trimethoprim/sulfadiazine is indicated where control of bacterial infections is required during treatment of:
Acute Strangles, Respiratory Tract Infections, Acute Urogenital Infections, Wound Infections and Abscesses
Trimethoprim/sulfadiazine is well tolerated by foals.
DOSAGE AND ADMINISTRATION:
Follow your Veterinarian's presciption instructions for your pet.
The recommended dose is 3.75 g trimethoprim/sulfadiazine per 110 lbs 50 kg body weight per day. Administer trimethoprim/sulfadiazine Powder orally once a day in a small amount of palatable feed.
The usual course of treatment is a single, daily dose for five to seven days.
Continue acute infection therapy for two or three days after clinical signs have subsided.
If no improvement of acute infections is seen in three to five days, re-evaluate diagnosis.
Trimethoprim/sulfadiazine may be used alone or in conjunction with intravenous dosing. Following treatment with trimethoprim/sulfadiazine 48% injection, therapy can be maintained using oral powder.
A complete blood count should be done periodically in patients receiving trimethoprim/sulfadiazine for prolonged periods. If significant reduction in the count of any formed blood element is noted, treatment
with trimethoprim/sulfadiazine should be discontinued.
Trimethoprim/sulfadiazine should not be used in horses showing marked liver parenchymal damage, blood dyscrasias, or in those with a history of sulfonamide sensitivity.
Do not use in horses intended for human consumption.
No adverse reactions of consequence have been noted following administration of trimethoprim/sulfadiazine. During clinical trials, one case of anorexia and one case of loose feces following treatment with the drug were reported.
Individual animal hypersensitivity may result in local or generalized reactions, sometimes fatal. Anaphylactoid reactions, although rare, may also occur. Antidote: Epinephrine.
It is common to find sulfa crystals in the animal's urine during a urinalysis a test on the urine, which does not pose a problem in animals that remain well hydrated.
Less commonly keratoconjunctivitis sicca KCS, dry eye may occur with long-term use of trimethoprim/sulfa.
Stop giving the medication and consult your veterinarian if your pet experiences discharge from the eye, redness of the eye, squinting, or other signs related to the eye.
Cats will drool excessively if allowed to taste the medication.
Other less common side effects include anemia resulting in pale gums and tiredness low platelets resulting in bleeding tendencies fever loss of appetite, vomiting diarrhea joint
inflammation arthritis resulting in lameness kidney damage resulting in increased thirst and urination and skin rashes with possible sensitivity to sunlight.
Stop giving the medication and consult your veterinarian if your pet experiences any of these signs.
If your pet experiences an allergic reaction to the medication, signs may include facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums,
cold limbs, or coma.
If you observe any of these signs, contact your veterinarian immediately.
Water should be readily available to horses receiving sulfonamide therapy.
TOXICITY AND SIDE EFFECTS:
Toxicity is low. The acute toxicity of trimethoprim/sulfadiazine is more than 5 g/kg orally in rats and mice. No significant changes were recorded in rats given doses of 600 mg/kg per day for 90 days.
Horses treated intravenously with trimethoprim/sulfadiazine 48% injection have tolerated up to five times the recommended daily dose for 21 consecutive days without clinical effects or histopathological changes.
Lengthening of clotting time was seen in some of the horses on high or prolonged dosing in one of two trials. The effect, which may have been related to a resolving infection, was not seen in a second similar trial.
Slight to moderate reductions in hematopoietic activity following high, prolonged dosage in several species have been recorded. This is usually reversible by folinic acid leucovorin administration or by stopping the drug. During long-term treatment of horses, periodic platelet counts and white and red blood cell counts are advisable.
The effect of trimethoprim/sulfadiazine on pregnancy has not been determined. Studies to date show that there is no detrimental effect on stallion spermatogenesis with or following the recommended dose of trimethoprim/sulfadiazine.