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K+BroVet Chew Tabs  [Potassium Bromide] was developed to provide a reliable source of potassium bromide. Potassium bromide has long been recognized as an excellent anti-convulsive for the alleviation of canine seizure disorders and is often considered the first option for dogs with idiopathic epilepsy. K Bro Vet has also been formulated with B vitamins to support healthy neurological function.  K BroVet can be used in conjunction with other therapies, including phenobarbital, or alone, as the sole anti-convulsive. Unlike phenobarbital, bromide is not a hepatotoxin, making it the treatment of choice for dogs with liver damage. Not for use in cats.  Oral solution is butterscotch-vanilla flavored chewable tablets are liver-flavored  Oral solution contains Vitamins B12 and B6 tablets contain Vitamin B12
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Item# Size/Desc Qty Price
04747
250 mg 60 cnt bottle
$18.99
$14.99
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04748
500 mg 60 cnt bottle
$32.99
$26.99
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**Note: This product requires a veterinarian's prescription to purchase.At checkout you will need to provide your veterinarian's FAX or email address. We will then send him or her a prescription verification that he or she will need to sign and return before we can ship you this product.



INDICATION:

Potassium bromide is used to treat seizure disorders in dogs. It can be used in addition to therapy with other agents or as the sole anticonvulsant.

CONTRAINDICATIONS:

K BROVET should not be used in animals with a history of hypersensitivity to Bromide or any of the components of the solution or tablets.

DOSAGE AND ADMINISTRATION:

It is important to follow your Veterinarians prescription instructions for your pet.
Recommended Dosage for K bullBROVET Oral Solution and Tablets:

To achieve a serum level of approximately 1 mg/mL, give 120 mg/kg PO daily for 5 days then reduce to 30 mg/kg PO once daily. To achieve a serum level of approximately 1.5 mg/mL, give 160 mg/kg PO for 5 days and then reduce to 40 mg/kg PO once daily thereafter. {R-21} Among dogs responses to bromide may vary, treatment should be tailored to the individual dog, based on serum bromide concentration, success of seizure control, and the observation of adverse effects.

Steady state serum concentrations generally take 4 to 5 months in dogs therapeutic concentrations may be reached before steady state at about 4 weeks after the beginning of treatment, serum bromide concentration may be tested to assess the response to product and, if results are satisfactory, the next testing for steady state serum levels is typically about 4 months.

If the dog's serum concentration is within range and the dog is doing well in the therapeutic range, serum concentration may then be tested every 6 to 12 months. Serum bromide is typically evaluated at the end of the loading period, then as described above when an animal is started with a loading dose. Dogs - An oral dose of 30 mg of Bromide per kg of body weight every twelve hours for 115 days produced a steady state serum concentration of 2.45 mg/mL range, 1.78 to 2.69 mg/mL in Beagles fed a diet containing 0.55% chloride. {R-3}

WARNINGS:

This medication should be used cautiously in older animals as they will be more susceptible to adverse effects. This medication is not indicated for use in cats.

Possible Side Effects:

Dog may experience drowsiness when taking K BROVET, but this will generally go away after approximately 3 weeks. Increased hunger, thirst, urination, vomiting, constipation, anorexia, and uncoordinated movements may occur with K BROVET. During the load in dose increased nausea may be experienced. There is no information on the relative frequency of pancreatitis in dogs associated with bromide therapy alone. However, pancreatitis has been reported to be more frequent in dogs on concurrent phenobarbital and bromide therapy than dogs on phenobarbital alone. {R-12} Personality changes have been occasionally reported in dogs on bromide, including attention seeking, irritability or aggression, and aimless pacing. Reproduction/Pregnancy/Lactation The effects of bromide on canine reproduction have not been studied. Young Dogs Safety of administering bromide to neonates and young animals has not been evaluated. {R-16-17} Drug interactions and/or related effects

Drug interactions and/or related effects:

Have been selected on the basis of their clinical significance possible mechanism in parentheses where appropriate - not necessarily inclusive »=major clinical significance: Note: Any of the following medications taken in combinations, depending on the amount taken, could also interact with K BROVET. Medications and foods containing chloride, bromide and chloride compete for reabsorption by the kidneys increased amounts of chloride can promote loss of bromide in the urine, leading to a lowering of serum bromide concentrations: Decreased chloride consumption will promote increased renal reabsorption of bromide. {R-1 2 4 5 7 15} Halothane anesthesia when inhaled a percentage of halothane is metabolized by dogs to produce bromide, along with other compounds peak serum concentration occurs within about a day and, in one group of dogs, ranged from 0.04 to 0.088 mg/mL and persisted, with some diminishment, for at least ten days.{R-10 11} Consideration should be given to animals that must have repeated anesthesia or that already require high serum bromide concentration for seizure control. Increased bromide levels due to metabolism of halothane are unlikely to be a significant risk for bromide toxicity in most dogs.



Storage Conditions: Store in a tightly sealed container at room temperature 59-86°F. Keep out of reach of children and animals. Manufactured For PRN PHARMACAL