Prednisone is a synthetic human corticosteroid, which reduces the effects of the immune system. This is used to treat allergies, immune-mediated diseases, autoimmune diseases and some types of cancer. This product is commonly employed by veterinarians to treat similar diseases in dogs and cats, however this product is not licensed for use in animals. There are no preparations containing prednisone which are approved by the FDA for use in animals as at June 2006.
Dosage and Administration
The dose rate used varies with the intended use of the product: anti-inflammatory doses are lower than immunosuppressive doses.
Warnings, Side Effects and Drug Interactions
Prednisone should not be used in animals with in viral infections, stomach ulcers, corneal ulcer, or Cushingoid syndrome. It should be used with caution in animals with diabetes, osteoporosis, blood clotting problems, elevated blood pressure, congestive heart failure, kidney disease or active tuberculosis. The insulin requirement of diabetic patients may increase when being treated with prednisone. Animals being treated with corticosteroids are more susceptible to secondary infections. The use of this product may delay wound healing.
Cushing's syndrome has been reported in association with prolonged or repeated corticosteroid therapy in dogs. Inhibition of the body's own steroid production following withdrawal of the drug may occur. Corticosteroids may induce the first stage of the birth process if used during the last trimester of pregnancy and may precipitate premature labor, which may be associated with complications. Additionally, corticosteroids administered to dogs, rabbits and rodents during pregnancy have resulted in birth defects in the young.
Muscle wasting may occur in association with corticosteroids, so a high dietary protein intake may be required with long term therapy. Metabolic changes may occur with protracted use of corticosteroids &ndash decreased levels of potassium in the blood in particular. Blood clotting problems may also occur &ndash small areas of bleeding may be seen under the skin.
Side effects, such as liver enzyme elevations, weight loss, anorexia, excessive drinking, urinating and eating are sometimes seen following the use of synthetic corticosteroids in dogs. Vomiting and diarrhea occasionally bloody have also been observed.
Should any signs of intolerance of prednisone occur in your pet, discontinue therapy and contact your veterinarian for advice.
Store at a controlled room temperature between 59-86°F 15-30°C.
Various generic manufacturers