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Gentizol is an antibacterial, anti-inflammatory, and antifungal ointment that is indicated for the treatment of canine acute and chronic otitis externa associated with yeast Malassezia pachydermatis, formerly Pityrosporum canis and/or bacteria susceptible to gentamicin. Each gram contains gentamicin sulfate, USP equivalent to 3 mg gentamicin base betamethasone valerate, USP equivalent to 1 mg betamethasone and 10 mg clotrimazole, USP in a mineral oil&ndashbased system containing a plasticized hydrocarbon gel. For otic use in dogs only.
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Item# Size/Desc Qty Price
165746
7.5 gm tube
$15.99
$7.99
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167546a
15 gm tube
$20.99
$10.99
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167546b
10 gm bottle
$19.99
$9.99
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167547
25 gm bottle
$22.99
$14.99
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167548
215 gm bottle
$84.99
$75.99
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Item qualifies for FREE SHIPPINGThis item requires a RX

**Note: This product requires a veterinarian's prescription to purchase.At checkout you will need to provide your veterinarian's FAX or email address. We will then send him or her a prescription verification that he or she will need to sign and return before we can ship you this product.



DOSAGE AND ADMINISTRATION:

Follow your Veterinarian's prescription instructions for your pet.

The external ear should be thoroughly cleaned and dried before treatment.
Remove foreign material, debris, crusted exudates, etc., with suitable non-irritating solutions. Excessive hair should be clipped from the treatment area.
After verifying that the eardrum is intact, instill 4 drops 2 drops from the 215 g. bottle of Gentizol ointment twice daily into the ear canal of dogs weighing less than 30 lbs.
Instill 8 drops 4 drops from the 215 g. bottle twice daily into the ear canal of dogs weighing 30 lbs. or more.
Therapy should continue for 7 consecutive days.

CONTRAINDICATIONS:

If hypersensitivity to any of the components occurs, treatment should be discontinued and appropriate therapy instituted. Concomitant use of drugs known to induce ototoxicity should be avoided. Do not use in dogs with known perforation of eardrums.

WARNINGS:

The use of gentamicin-betamethasone-clotrimazole ointment has been associated with deafness or partial hearing loss in a small number of sensitive dogs e.g., geriatric. The hearing deficit is usually temporary. If hearing or vestibular dysfunction is noted during the course of treatment, discontinue use of gentamicin-betamethasone-clotrimazole ointment immediately and flush the ear canal thoroughly with a non-ototoxic solution. Corticosteroids administered to dogs, rabbits, and rodents during pregnancy have resulted in cleft palate in offspring. Other congenital anomalies including deformed forelegs, phocomelia, and anasarca have been reported in offspring of dogs which received corticosteroids during pregnancy. Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition if used during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta and metritis.

PRECAUTIONS:

Identification of infecting organisms should be made either by microscopic roll smear evaluation or by culture as appropriate. Antibiotic susceptibility of the pathogenic organisms should be determined prior to use of this preparation. If overgrowth of nonsusceptible bacteria, fungi or yeasts occur, or if hypersensitivity develops, treatment should be discontinued and appropriate therapy instituted. Administration of recommended doses of Gentizol ointment beyond 7 days may result in delayed wound healing. Avoid ingestion. Adverse systemic reactions have been observed following the oral ingestion of some topical corticosteroid preparations. Patients should be closely observed for the usual signs of adrenocorticoid overdosage which include sodium retention, potassium loss, fluid retention, weight gain, polydipsia and/or polyuria. Prolonged use or overdosage may produce adverse immunosuppressive effects. Use of corticosteroids, depending on dose, duration, and specific steroid, may result in endogenous steroid production inhibition following drug withdrawal. In patients presently receiving or recently withdrawn from corticosteroid treatments, therapy with a rapidly acting corticosteroid should be considered in especially stressful situations. Before instilling any medication into the ear, examine the external ear canal thoroughly to be certain the tympanic membrane is not ruptured in order to avoid the possibility of transmitting infection to the middle ear as well as damaging the cochlea or vestibular apparatus from prolonged contact.

TOXICOLOGY:

Clinical and safety studies with Gentamicin sulfate USP, Betamethasone valerate, USP and Clotrimazole, USP ointment have shown a wide safety margin at the recommended dose level in dogs see PRECAUTIONS/SIDE EFFECTS.

SIDE EFFECTS:

Gentamicin: While aminoglycosides are absorbed poorly from skin, intoxication may occur when aminoglycosides are applied topically for prolonged periods of time to large wounds, burns, or any denuded skin, particularly if there is renal insufficiency. All aminoglycosides have the potential to produce reversible and irreversible vestibular, cochlear and renal toxicity.

Betamethasone: Side effects such as SAP and SGPT enzyme elevations, weight loss, anorexia, polydipsia, and polyuria have occurred following the use of parenteral or systemic synthetic corticosteroids in dogs. Vomiting and diarrhea occasionally bloody have been observed in dogs and cats. Cushing&rsquos Syndrome in dogs has been reported in association with prolonged or repeated steroid therapy.

Clotrimazole: The following have been reported occasionally in humans in connection with the use of clotrimazole: erythema, stinging, blistering, peeling, edema, pruritus, urticaria, and general irritation of the skin not present before therapy.