GenOne Topical Spray is a gentamicin sulfate with betamethasone valerate topical spray that is indicated for the treatment in dogs of infected superficial lesions for bacteria sensitive to gentamicin. Each milliliter contains gentamicin sulfate equivalent to 0.57 mg gentamicin base, and betamethasone valerate equivalent to 0.284 mg betamethasone.
Gentamicin, a broad-spectrum antibiotic, is a highly effective topical treatment for bacterial infections of the skin. Betamethasone valerate, a synthetic glucocorticoid, has been shown to provide anti-inflammatory and antipruritic activity in the topical management of corticosteroid-responsive infected superficial lesions in dogs. For topical use in dogs only.Add this item to your cart:
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INDICATIONS: For the treatment of infected superficial lesions in dogs caused by bacteria sensitive to gentamicin.
If hypersensitivity to any of the components occurs, treatment with this product should be discontinued and appropriate therapy instituted.
DOSAGE AND ADMINISTRATION:
Prior to treatment, remove excessive hair and clean the lesion and adjacent area.
Hold bottle upright 3 to 6 inches from the lesion and depress the sprayer head twice.
Administer 2 to 4 times daily for 7 days.
Each depression of the sprayer head delivers 0.7 mL of GenOne&trade Spray.
GenOne&trade Spray was well tolerated in an abraded skin study in dogs. No treatment-related toxicological changes in the skin were observed.
Systemic effects directly related to treatment were confined to histological changes in the adrenals, liver, and kidney and to organ-to-body weight ratios of adrenals. All were dose related, were typical for or not unexpected with corticosteroid therapy, and were considered reversible with cessation of treatment.
POSSIBLE SIDE EFFECTS:
Side effects such as SAP and SGPT enzyme elevations, weight loss, anorexia, polydipsia, and polyuria have occurred following parenteral or systemic use of synthetic corticosteroids in dogs. Vomiting and diarrhea occasionally bloody have been observed in dogs.
Cushing&rsquos syndrome in dogs has been reported in association with prolonged or repeated steroid therapy.
Antibiotic susceptibility of the pathogenic organisms should be determined prior to the use of this preparation. Use of topical antibiotics may permit overgrowth of non-susceptible bacteria, fungi, or yeasts. If this occurs, treatment should be instituted with other appropriate agents as indicated.
Administration of recommended dose beyond 7 days may result in delayed wound healing. Animals treated longer than 7 days should be monitored closely.
Avoid ingestion. Oral or parenteral use of corticosteroids, depending on dose, duration, and specific steroid may result in inhibition of endogenous steroid production following drug withdrawal.
In patients presently receiving or recently withdrawn from systemic corticosteroid treatments, therapy with a rapidly acting corticosteroid should be considered in especially stressful situations.
If ingestion should occur, patients should be closely observed for the usual signs of adrenocorticoid overdosage which include sodium retention, potassium loss, fluid retention, weight gains, polydipsia, and/or polyuria. Prolonged use or overdosage may produce adverse immunosuppressive effects.
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