Dicural Tabs [Difloxacin HCl] is a fluoroquinolone with broad-spectrum antimicrobial activity against Gram-positive and Gram-negative microorganisms. Tablets are indicated for the management of diseases in dogs associated with bacteria susceptible to difloxacin. For oral use in dogs only.Add this item to your cart:
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DOSAGE AND ADMINISTRATION: The dose range of difloxacin in dogs is 5 to 10 mg/kg body weight 2.3 to 4.6 mg/lb once a day for two to three days beyond the cessation of clinical signs to a maximum of 30 days see
The determination of dosage for any particular patient must take into consideration such factors as the severity and nature of the infection, the susceptibility of the causative organism, and the integrity of the host-defense mechanisms. The dose of 5 mg/kg of body weight administered once daily should be used for the routine treatment of infection caused by susceptible organisms in an otherwise healthy dog. The dosage may be increased to the upper limit of the dose range 10 mg/kg, if deemed necessary. Antibiotic susceptibility of the pathogenic organisms should be determined prior to use of difloxacin. However, therapy with DICURAL tablets may be initiated before results of these tests are known. Once test results become available, continue with appropriate therapy.
For the treatment of skin and soft tissue infections, DICURAL tablets should be given for two 2 to three 3 days beyond the cessation of clinical signs to a maximum of 30 days. For the treatment of urinary tract infections, DICURAL tablets should be administered for at least 10 consecutive days. If no improvement is noted within five 5 days, the diagnosis should be re-evaluated and a different course of therapy considered.
Table 1. Dose Table for DICURAL tablets for Dogs
2.3 kg 5 lb
1.1 kg 2.5 lb
9 kg 20 lb
4.5 kg 10 lb
27 kg 60 lb
13.5 kg 30 lb
Compounds e.g., sucralfate, antacids, and multivitamins containing divalent and trivalent cations e.g., iron, aluminum, calcium, magnesium and zinc may substantially interfere with the absorption of quinolones from the intestinal tract resulting in a decrease in product bioavailability. Therefore, the concomitant oral administration of quinolones with foods, supplements or other preparations containing these compounds should be avoided.
Difloxacin hydrochloride has been administered to dogs concurrently with other animal health products under field conditions with no adverse effects observed. Concurrent therapies included heartworm prevention, thyroid hormone augmentation, ectoparasiticides anesthetics, anti-seizure compounds, topical antibiotics/anti-inflammatory and antihistamine medication.
Difloxacin and other quinolones have been shown to cause arthropathy in immature animals of most species tested, the dog being particularly sensitive to this side effect. Difloxacin is contraindicated in immature dogs during the rapid growth phase between 2 and 8 months of age in small and medium-sized breeds, and up to 18 months of age in large and giant breeds.
Quinolone-class drugs should be used with caution in animals with known or suspected central nervous system CNS disorders. In such animals, quinolones have in rare instances, been associated with CNS stimulation which may lead to convulsive seizures. Quinolones have been shown to produce erosions of cartilage of weight-bearing joints and other signs of arthropathy in immature animals of various species.
The safety of DICURAL tablets in breeding or pregnant dogs has not been determined. DICURAL tablets should not be used in dogs known to be hypersensitive to quinolones.
For use in animals only. Keep out of the reach of children.
Avoid contact with eyes. In case of contact, immediately flush eyes with copious amounts of water for 15 minutes. In case of dermal contact, wash skin with soap and water. Consult a physician if irritation persists following ocular or dermal exposure. Individuals with a history of hypersensitivity to quinolones should avoid this product. In humans, there is a risk of user photosensitization within a few hours after excessive exposure to quinolones. If excessive accidental exposure occurs, avoid direct sunlight.
Various breeds of dogs, aged 9 months to 16 years, were admitted into the clinical study and received 5 mg/kg/day for up to 10 days. DICURAL tablets were well tolerated. Potential adverse reactions recorded in clinical cases involved the gastrointestinal tract e.g., anorexia, emesis, diarrhea, and inappetence, which were self-limiting and did not require additional treatment.
Store DICURAL tablets between 15°C and 30°C 59°F and 86°F avoid excessive heat 40°C/104°F.
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