Vetoryl, Trilostane, Canine Cushing's Disease
Vetoryl or Trilostane is an adrenocortical suppressant for oral use in dogs only and is used for the treatment of hyperadrenocorticism, also known as Cushing's Disease. Cushing's Disease is a condition where too much of the hormone cortisol is produced.Add this item to your cart:
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What is Cushing's Syndrome?:
Hyperadrenocorticism, or Cushing's syndrome, is one of the most commonly diagnosed canine endocrine disorders. Cushing's Syndrome is usually in older dogs and can be either spontaneous or iatrogenic.
The signs of Cushing's Syndrome in dogs arise due to an excess of circulating gucocorticoids, particularly cortisol. Cortisol is a hormone produced in the cortex of the adrenal glands. The normal function of cortisol is to help the body respond to stess and change, and also to prepare the body for the flight or fight response. Cortisol movilizes nutrients, modifies the body's response to inflammation, stimulates the liver to raise the blood sugar, and helps control the amount of water in the body.
Signs of Cushing's Syndrome:
Excess levels of glucocorticoids in the body cause a range of clinical signs that include:
* polydipsia=increased thirst
* polyuria=is a condition usually defined as excessive or abnormally large production and/or passage] of urine
* pot belly
* thinning of the skin
* hair loss
* recurrent skin diseases
* excessive panting
Benefits of Vetoryl:
* Promising treatment for Cushing's Disease in dogs
* Treats both pituitary-dependent and adrenal-dependent cases
* Fewer & less severe side-effects reported than Mitotane
* Controls excess production of cortisol
How does it work:
VETORYL Capsules are available in 3 sizes 10, 30 and 60 mg for oral administration based on body weight. Trilostane 4a, 5a-epoxy-17ß-hydroxy-3-oxoandrostane-2a-carbonitrile is an orally active synthetic steroid analogue that selectively inhibits 3 ß-hydroxysteroid dehydrogenase in the adrenal cortex, thereby inhibiting the conversion of pregnenolone to progesterone. This inhibition blocks production of glucocorticoids and to a lesser extent, mineralocorticoids and sex hormones while steroid precursor levels increase.
Vetoryl, Trilostane, Canine Cushing's Disease
DOSAGE AND ADMINISTRATION:
Always completely read the Client Information Sheet with prescription.
The starting dose for the treatment of hyperadrenocorticism in dogs is 1.0-3.0 mg/lb 2.2-6.7 mg/kg once a day based on body weight and capsule size. Follow your Veterinarians prescription dosage that will be dependent on the weight of your pet.
VETORYL Capsules should be administered with food.
Individual dose adjustments and close monitoring are essential.
Your Veterinarian will Re-examine and conduct an ACTH stimulation test 10-14 days after every dose alteration. Care must be taken during dose increases to monitor the dog's clinical signs and serum electrolyte concentrations. Once daily administration is recommended. However, if clinical signs are not controlled for the full day, twice daily dosing may be needed. To switch from once daily to twice daily dosing, increase the total daily dose by 1/3 to 1/2 and divide the total amount into two doses given 12 hours apart.
Once an optimum dose of VETORYL Capsules has been reached, re-examine the dog at 30 days, 90 days and every 3 months thereafter. At a minimum, this monitoring should include a thorough history and physical examination, ACTH stimulation test conducted 4-6 hours after VETORYL Capsule administration, and serum biochemical tests with particular attention to electrolytes, renal and hepatic function. Good control is indicated by favorable clinical signs as well as post-ACTH serum cortisol of 1.45-9.1 &mug/dL 40-250 nmol/L.
The use of VETORYL Capsules is contraindicated in dogs that have demonstrated hypersensitivity to trilostane. Do not use VETORYL Capsules in animals with primary hepatic disease or renal insufficiency. Do not use in pregnant dogs. Studies conducted with trilostane in laboratory animals have shown teratogenic effects and early pregnancy loss. WARNINGS: mineralocorticoids and intravenous fluids may be required. Angiotensin-converting enzyme ACE inhibitors should be used with caution with VETORYL Capsules, as both drugs have aldosterone-lowering effects which may be additive, impairing the patient's ability to maintain normal electrolytes, blood volume and renal perfusion. Potassium sparing diuretics e.g. spironolactone should not be used with VETORYL Capsules, as both drugs have the potential to inhibit aldosterone, increasing the likelihood of hyperkalemia.
Keep out of reach of children. Not for human use. Wash hands after use. Do not empty capsule contents and do not attempt to divide the capsules. Do not handle the capsules if pregnant or if trying to conceive. Trilostane is associated with teratogenic effects and early pregnancy loss in laboratory animals. In the event of accidental ingestion/overdose, seek medical advice immediately and take the labeled container with you.
Hypoadrenocorticism can develop at any dose of VETORYL Capsules. In some cases, it may take months for adrenal function to return and some dogs never regain adequate adrenal function. A small percentage of dogs may develop corticosteroid withdrawal syndrome within 10 days of starting treatment. This phenomenon results from acute withdrawal of circulating glucocorticoids clinical signs include weakness, lethargy, anorexia, and weight loss. The use of VETORYL Capsules will not affect the adrenal tumor itself. Adrenalectomy should be considered as an option for cases that are good surgical candidates. The safe use of this drug has not been evaluated in lactating dogs and males intended for breeding.
The most common adverse reactions reported are poor/reduced appetite, vomiting, lethargy/dullness, diarrhea, and weakness. Occasionally, more serious reactions, including severe depression, hemorrhagic diarrhea, collapse, hypoadrenocortical crisis or adrenal necrosis/rupture may occur, and may result in death.
For a copy of the Material Safety Data Sheet MSDS, or to report adverse reactions, call Dechra Veterinary Products at 866 933-2472.
INFORMATION FOR DOG OWNERS:
Owners should be aware that the most common adverse reactions may include: an unexpected decrease in appetite, vomiting, diarrhea, or lethargy and should receive the Client Information Sheet with the prescription. Owners should be informed that control of hyperadrenocorticism should result in resolution of polyphagia, polyuria and polydipsia. Serious adverse reactions associated with this drug can occur without warning and in rare situations result in death see ADVERSE REACTIONS. Owners should be advised to discontinue VETORYL Capsules and contact their veterinarian immediately if signs of intolerance are observed. Owners should be advised of the importance of periodic follow-up for all dogs during administration of VETORYL Capsules.
Store at controlled room temperature 25°C 77°F with excursions between 15°-30°C 59°-86°F permitted.
VETORYL Capsules are available in 10, 30 and 60 mg strengths, packaged in aluminum foil blister cards of 10 capsules, with 3 cards per carton.
APPROVED BY FDA. Distributed by: Dechra Veterinary Products, 7015 College Boulevard, Suite 525, Overland Park,
VETORYL is a trademark of Dechra Ltd
Vetoryl is a registered trademark of Dechra Veterinary Products. The information provided on this website is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. We reference Dechra as the source for our information, you may research this product further at the Dechra webpage: http://www.dechra-us.com/files/dechraUSA/downloads/Product%20inserts/Vetoryl.pdf You should always consult your own veterinarian for specific advice concerning the diagnosis, and treatment of your pet. As stated the information provided is for educational purposes to aid you in purchasing your pet's medication, it is not a substitute for a veterinary exam, nor does this information suggest that this medication will be tolerated by your pet or that your pet will not experience side effects.
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